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You might want to have a look at this article if Windows Defender is your primary A/V in Windows 10.
www.bleepingcomputer.com

New TrickBot Version Focuses on Microsoft's Windows Defender
A new version of the TrickBot banking Trojan continues its evolution of targeting security software in order to prevent its detection and removal. In this new version, TrickBot has set its sights on Windows Defender, which for many people is the only antivirus installed on a Windows 10 machine.